Relative reactivity of alcohols in dehydration process:

The large temperature increase significantly boosts the alkylating power of weak alkylating agents such as alcohols, carboxylic acid esters, and ethers derived from weak Brönsted acids, which are only weak alkylating agents at room temperature.

(iii) Williamson ether synthesis.

is required for this reaction. Often, mercury trifluoroacetate (Hg(OCOCF3)2) is used as a catalyst for the reaction, geneating an ether with regiochemistry. Using similar reactions, are used as for alcohols.


(i) Oxidation of a primary alcohol to carboxylic acid.

(ii) Oxidation of a primary alcohol to aldehyde.

The catalytic Williamson ether synthesis (CWES) at high temperatures is especially well-suited for the production of alkyl aryl ethers such as anisole, neroline, and 4-methyl anisole which are of industrial importance.


Williamson ether synthesis - Revolvy

This direct reaction requires elevated temperatures (about 125 °C). The reaction is catalyzed by acids, usually sulfuric acid. The method is effective for generating symmetrical ethers, but not unsymmetrical ethers. Diethyl ether is produced from ethanol by this method. Cyclic ethers are readily generated by this approach. Such reactions must compete with dehydration of the alcohol:

11.08.2017 · Williamson ether synthesis ..

Alcohol acts as a base. The oxygen atom on the hydroxyl group of alcohol contains lone pair of electrons. These lone pair of electrons attack on the proton from the sulfuric acid. This forms the protonated alkyloxonium ion.

Williamson Ether Synthesis - University of Calgary

Alkenes are formed from alcohol by the dehydration process. Alcohols undergo elimination reaction mechanism (E1 or E2) to form alkenes. This occurs by heating alcohols in the presence of strong acid, for example, H2SO4 at high temperatures. The reaction can be understood more from the reaction below:

06.01.2018 · Synthesis of Ethers

Williamson Ether Synthesis reaction is a synthesis reaction which synthesizes ether from alcohol. In the first step, an alkoxide ion is generated form an alcohol. This occurs by the reaction of an alcohol with sodium metal. Hydrogen gas is evolved as a byproduct of the reaction.

williamson ether synthesis reaction type

The Williamson ether synthesis of allyl phenyl ether and its subsequent Claisen rearrangement to 2-allylphenol introduces two important reactions of ethers to the undergraduate laboratory.