Williamson ether synthesis - Wikipedia

Both reactants in the Williamson ether synthesis usually originate in alcohol precursors. Sodium and potassium alkoxides are prepared by reaction of an alcohol with the appropriate metal, and alkyl halides are most commonly made from alcohols by reaction with a hydrogen halide (Section 4.8), thionyl chloride (Section 4.14), or phosphorus tribromide (Section 4.14). Alternatively, alkyl p-toluenesulfonates may be used in place of alkyl halides; alkyl p-toluenesulfonates are also prepared from alcohols as their immediate precursors (Section 8.14).

Williamson Ether Synthesis - Chemistry LibreTexts

The monomers used for the polymerization were synthesized using a Williamson ethersynthesis and electrophilic aromatic subs...(SO-PPV) via a SN2 reaction have also proven to be difficult, but a 100% and 25% functionalized SO-PPV prod...


Williamson Ether Synthesis - Chemistry Class

The reaction is named for Alexander Williamson, a British chemist who used it to prepare diethyl ether in 1850.

Next, in what amounts to an intramolecularWilliamson ether synthesis, the alkoxide oxygen attacks the carbon that bears the halide leaving group, giving an epoxide. As in other nucleophilic substitutions, the nucleophile approaches carbon from the side opposite the bond to the leaving group:


Williamson Ether Synthesis Reaction Mechanism Examples - Duration: ..

The Williamson ether synthesis is an , forming an from a and an . This reaction was developed by in1850 .Typically it involves the reaction of an with aprimary alkyl via an . This reaction is important in the history of organicchemistry because it helped prove the structure of .

Williamson ether synthesis - Organic chemistry

In the case of asymmetrical ethers there are two possibilitiesfor the choice of reactants, and one is usually preferable eitheron the basis of availability or reactivity. The Williamson reactionis also frequently used to prepare an ether indirectly from twoalcohols. One of the alcohols is first converted to a leaving group(usually ), then the two are reactedtogether.

Williamson Ether Synthesis Experiment

A typical Williamson reaction is conducted at 50–100°C and iscomplete in 1–8 hours. Often the complete disappearance of thestarting material is difficult to achieve, and side reactions arecommon. Yields of 50–95% are generally achieved in laboratorysyntheses, while near-quantitative conversion can be achieved inindustrial procedures.

Preparation of Ethers :Williamson’s synthesis – …

A typical Williamson reaction is conducted at 50–100°C and iscomplete in 1–8 hours. Often the complete disappearance of thestarting material is difficult to achieve, and side reactions arecommon. Yields of 50–95% are generally achieved in laboratorysyntheses, while near-quantitative conversion can be achieved inindustrial procedures.

What is Williamson's ether synthesis? - Updated 2017 - …

PROBLEM 16.7Only one combination of alkyl halide and alkoxide is appropriate for the preparation of each of the following ethers by the Williamson ether synthesis. What is the correct combination in each case?