Methods: The syntheses of some novel fluorine based 2-aminothiazoles have been described by using hypervalent iodine [I(III)] mediated approach. It was observed that this is the more general and promising method for the synthesis of any thiazole, but, when other methods work, the hypervalent iodine [I(III)] mediated approach generally gives better yields. The structures of these compounds have been characterized from the rigorous analysis of their IR, 1H NMR, MS and elemental analysis. These compounds were screened for their anti-microbial activity.
For a comparative study of yield (%), the title compounds 7a-g, 10a-c and 14a-f were also prepared by Hantzsch thiazole synthesis. Outline of which is shown in Scheme 4.
we report the synthesis of aminothiazoles from thiourea and ..
As shown in Table 1, the comparison of yields (%) relating to the compounds synthesized from the recently known hypervalent iodine mediated approach and those from earlier method reveals that I(III) mediated approach is superior to the conventional Hantzsch thiazole synthesis.