Synthetic biological approaches to natural product biosynthesis.

Walton, Hong Luo, and Heather Hallen-Adams -- The Pictet-Spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: a novel function for a nonribosomal peptide synthetase / Kento Koketsu [and others] -- Discovery and biosynthesis of phosphonate and phosphinate natural products / Spencer C.

01/12/2011 · Synthetic Biological Approaches to Natural ..

Additionally, InMed’s biosynthesis process can produce all of the 90+ cannabinoids naturally found in cannabis, enabling the company to avoid the harmful chemicals that are used in the cannabis growing process and offering an easier way to scale-up from the laboratory to full production.

The company’s preclinical development pipeline includes INM-750 for the treatment of epidermolysis bullosa (EB), an orphan pediatric disease with no currently approved therapy.


Synthetic biological approaches to natural product ..

New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters[J].

This paper demonstrates the significant utility of deploying non-traditional biological techniques to harness available volatiles and waste resources on manned missions to explore the Moon and Mars. Compared with anticipated non-biological approaches, it is determined that for 916 day Martian missions: 205 days of high-quality methane and oxygen Mars bioproduction with Methanobacterium thermoautotrophicum can reduce the mass of a Martian fuel-manufacture plant by 56%; 496 days of biomass generation with Arthrospira platensis and Arthrospira maxima on Mars can decrease the shipped wet-food mixed-menu mass for a Mars stay and a one-way voyage by 38%; 202 days of Mars polyhydroxybutyrate synthesis with Cupriavidus necator can lower the shipped mass to three-dimensional print a 120 m3 six-person habitat by 85% and a few days of acetaminophen production with engineered Synechocystis sp. PCC 6803 can completely replenish expired or irradiated stocks of the pharmaceutical, thereby providing independence from unmanned resupply spacecraft that take up to 210 days to arrive. Analogous outcomes are included for lunar missions. Because of the benign assumptions involved, the results provide a glimpse of the intriguing potential of ‘space synthetic biology’, and help focus related efforts for immediate, near-term impact.


Biosynthesis of therapeutic natural products using synthetic ..

coli-based expression systems in comparison to other approaches; maximizing production of cannabinoids and related compounds through gene optimization; and additional proprietary developments and data related to InMed’s breakthrough biosynthesis program.

Why Natural Products? - Scripps Research Institute

The difficulty, tedium, costliness and time-consuming nature of the process is, overall, off-putting and creates a great deal of chemical waste.

The proprietary cannabinoid manufacturing process pioneered by InMed addresses this problem through biosynthesis, which is the process of utilizing naturally occurring cannabinoid DNA to produce cannabinoid compounds in a laboratory setting.

Combining biological and chemical approaches for …

(CSE: IN) (OTC: IMLFF) is scientifically bypassing the horticultural approach to cannabinoid production by developing a robust, high-yield biosynthesis process.

Combining biological and chemical approaches ..

InMed’s approach to developing biosynthetic cannabinoids combines the inherent safety and established efficacy of natural drug structures with the kind of quality-controlled pharmaceutical manufacturing required by the FDA.

while pure chemical synthetic routes exist, biosynthesis ..

InMed is taking a very unique approach by focusing on a proprietary cannabinoid manufacturing process that sets it apart as a catalyst of improvement in the availability of pharmaceutical-grade cannabinoids.

The company’s proprietary biosynthesis process has the ability to combine the intrinsic safety and efficacy of natural drug structures with the convenience, control and quality of a laboratory-based manufacturing process.