AB - A new approach has been developed for the resolution of carbonyl compounds possessing an asymmetric carbon atom by means of a bifunctional intermediate which possesses a free acid group and a group which reversibly condenses with the carbonyl compound. For this purpose, 4-(4-carboxyphenyl)-semicarbazide has been synthesized and its use assayed in a successful resolution of dl-3-methylcyclohexanone.
Other exposures may induce the synthesis of a protective protein in the body. The best example is probably metallothionein, which binds cadmium and promotes the excretion of this metal; cadmium exposure is one of the factors that result in increased expression of the metallothionein gene. Similar protective proteins may exist but have not yet been explored sufficiently to become accepted as biomarkers. Among the candidates for possible use as biomarkers are the so-called stress proteins, originally referred to as heat shock proteins. These proteins are generated by a range of different organisms in response to a variety of adverse exposures.
Semicarbazide Hydrochloride For Synthesis | VWR
A series of 4-aminomethylpyridazines and -pyridazin-3(2)-ones (“diaza-benzylamines”), bearing alkylamino side chains in position relative to the CH2NH2 unit, was synthesized by catalytic hydrogenation of the corresponding nitriles in strongly acidic medium. -Benzyl protecting groups either at the pyridazinone ring nitrogen or at an exocyclic nitrogen were selectively removed hydrogenolytically or by treatment with a Lewis acid. The new compounds were tested for semicarbazide-sensitive amine oxidase (SSAO) inhibitory activity and 4-(aminomethyl)-,′-diethylpyridazine-3,5-diamine (22) was found to be the most active representative.