Quinazoline nucleus is an interesting molecule among the most important classes of an aromatic bicyclic compounds with two nitrogen atoms in their structure. It is consisting of aromatic benzopyrimidine system made up of two fused six member simple aromatic rings benzene and pyrimidine ring  .
Ilangovan P, Ganguly S, Pandi V, Stables JP, Stables, Design and synthesis of novel quinazolinone derivatives as broad spectrum anticonvulsants, Sch. Res. Lib., 2010; (1): 13-21.
Synthesis of quinazoline compounds containing α-aminophosphonat.
El-helby AG, Abdel wahab MH, Design and synthesis of some new derivatives of 3H- quinazolin-4-one with promising anticonvulsant activity, Acta Pharm., 2003; (53): 127–138.
Facile Preparation of 4-Substituted Quinazoline Derivatives
Patel HU, Patel RS, Patel CN, Synthesis and Antihypertensive Activity of Some Quinazoline Derivatives, J. App. Pharma. Sci., 2013; (3): 171-174.
Method Optimization for Synthesis of Trisubstitued Quinazoline ..
Aanandhi MV, Velmurugan V, Shanmugapriya S, Synthesis, characterization and biological evaluation of 3,4-Dihydro quinazoline2(H)-one derivatives, J. of Chem and Pharm. Res., 2011; (2): 676-683.
Synthesis and characterization of quinazoline derivatives: ..
Alafeefy AM, Kadi AA, Al-Deeb OA, Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives, Eur. J. Med. Chem., 2010; (45): 4947-4952.
New octahydroquinazoline derivatives: synthesis and ..
Rajveer CH, Swarnalatha CH, Stephen RB, Sudhrshini S, Synthesis of 6-Bromo-oxo quinazoline derivatives and their pharamcological activities, Int. J. Chem. Res., 2010; (1): 21-24.
SYNTHESIS OF NEW QUINAZOLINE DERIVATIVES ..
Objective: To synthesis evaluation of the analgesic and anti-inflammatory activities of pyrazoline bearing 4(3H)-quinazolinone derivatives.
and Theoretical Studies of Quinazoline-2,4-dione Derivatives
The synthesized quinazolinone Schiff bases (1) and (2) established their structures by elemental analysis, spectroscopic techniques, and X-ray diffraction studies. They have shown anticancer potential against MCF7 breast cancer cells. It was found out that compounds possess the capability of inducing intrinsic and externsic apoptosis pathway, which was well regulated by caspase enzymes. Moreover, the active role of mitochondria in the cell death was confirmed by reducing the MMP, release of cytochrome c, and ROS elevation. Our results showed that compounds are promising anticancer agents. However, further research in the area of in vivo studies on the compounds might be vital for the development of new pharmaceuticals drugs.