93. Su Y, He Y, Lu H, Sai L, Li Q, Li W. . The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating. 2009;30:19-25
MMP-9 gene silencing in BMVEC by QD-siRNAMMP-9 nanoplexes: BMVECs were transfected with QD-siRNAMMP-9 or Xtreme-siRNAMMP-9 or Xtreme siRNAscrambled for 48 h. RNA was extracted, reverse transcribed, cDNA amplified and MMP-9 gene expression was determined by real-time, quantitative PCR. Relative expression of mRNA species was calculated using the comparative CT method. Data are the mean ± SD of 3 separate experiments done in duplicate. Statistical significance was determined using ANOVA based comparing QD-siRNAMMP-9 nanoplexes to the negative control samples. Reprinted from Brain Research, 1282, Adela Bonoiu, Supriya D. Mahajan, Ling Ye, Rajiv Kumar, Hong Ding, Ken-Tye Yong, Indrajit Roy, Ravikumar Aalinkeel, Bindukumar Nair, Jessica L. Reynolds, Donald E. Sykes, Marco A. Imperiale, Earl J. Bergey, Stanley A. Schwartz, Paras N. Prasad, gene silencing by a quantum dot-siRNA nanoplex delivery to maintain the integrity of the blood brain barrier, 142-155, Copyright (2009), with permission from Elsevier.
Controllable synthesis of CdS quantum dots ..
25. Ozkan M. Quantum dots and other nanoparticles: what can they offer to drug discovery?. 2004;9:1065-71 doi: 10.1016/s1359-6446(04)03291-x
Quantum Dot Production - News Medical
(a) Absorption and emission of rhodamine red, a common organic dye, and genetically-encoded DsRed2 protein. (b) Absorption and emission of different QD dispersions. The black line shows the absorption of the 510-nm-emitting QDs. (c) Photo demonstrating the size-tunable luminescence properties and spectral range of the six QD dispersions plotted in b versus CdSe core size. All samples were excited at 365 nm. Reprinted by permission from Macmillan Publishers Ltd: Nature Materials (Medintz IL, Uyeda HT, Goldman ER, Mattoussi H. Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater. 2005; 4: 435-46., ), copyright 2005.
Most chemists have studied quantum dots for their basic properties
54. Dabbousi BO, Rodriguez-Viejo J, Mikulec FV, Heine JR, Mattoussi H, Ober R. . (CdSe)ZnS Core-Shell Quantum Dots: Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites. 1997;101:9463-75
Zinc Oxide—From Synthesis to Application: A Review - MDPI
Quantum dots (QDs) are luminescent nanocrystals with rich surface chemistry and unique optical properties that make them useful as probes or carriers for traceable targeted delivery and therapy applications. QDs can be functionalized to target specific cells or tissues by conjugating them with targeting ligands. Recent advancement in making biocompatible QD formulations has made these nanocrystals suitable for applications. This review provides an overview of the preparation of QDs and their use as probes or carriers for traceable, targeted therapy of diseases and . More specifically, recent advances in the integration of QDs with drug formulations for therapy and their potential toxicity and are highlighted. The current findings and challenges for optimizing QD/drug formulations with respect to optimal size and stability, short-term and long-term toxicity, and applications are described. Lastly, we attempt to predict key trends in QD/drug formulation development over the next few years and highlight areas of therapy where their use may provide breakthrough results in the near future.
Nanoscience and Nanotechnology Letters
62. Derfus AM, Chan WCW, Bhatia SN. Intracellular Delivery of Quantum Dots for Live Cell Labeling and Organelle Tracking. 2004;16:961-6