Synthesis and Hydrogenation of Disubstituted Chalcones…

Following our previous report on the synthesis of adamantane derivatives by condensation of 4,4-disubstituted cyclohexanone enamines with α,β- unsaturated acid chlorides, we now report the synthesis of seven new substituted adamantanediones from the reactions of three cyclohexanone enamines (4, Y=phenyl, isopropenyl, methyl) in which one of the substituents is an acetyl group.

“Novel Synthesis of Cis-3,5-disubstituted Morpholine Derivatives.”  71 (12): 4678–4681.

N2 - Asymmetric synthetic methodology is introduced for preparation of 3,3-disubstituted cyclopentanones, including (+)-α-cuparenone, of high enantiomeric purity.


Fluorous Synthesis of Disubstituted Pyrimidines

“Novel Synthesis of Cis-3,5-disubstituted Morpholine Derivatives.”  71.12 (2006): 4678–4681.

Asymmetric synthetic methodology is introduced for preparation of 3,3-disubstituted cyclopentanones, including (+)-α-cuparenone, of high enantiomeric purity.


Synthesis, spectral characteristics and structure of 1,3 ..

N2 - 1,3-Disubstituted hexahydropyrimidin-5-yl(phenyl)methanone (products 1-5) were prepared from the reaction of dibenzoylmethane with primary amines and formaldehyde in the presence of Lewis acid catalyst at ambient temperature. Replication of the reaction with acetylacetone and ethyl aetoacetate yielded 1,1′-(1,3-disubstituted hexahydropyrimidine-5,5-diyl)diethanone (products 6-10) and ethyl 5-acetylhexahydropyrimidine-5-carboxylate (products 11-13), respectively. Yields obtained ranged from 69 to 89%.

Spectral Characteristics and Structure of 1,3- and ..

AB - Asymmetric synthetic methodology is introduced for preparation of 3,3-disubstituted cyclopentanones, including (+)-α-cuparenone, of high enantiomeric purity.

Journal of the Brazilian Chemical Society ..

Grimaldi, et al., 1,4-Disubstituted-[1,2,3] triazolylcontaining analogues of MT-Ⅱ:design, synthesis, conformational analysis, and biological activity, J.

Synthesis, urease inhibition ..

1,3-Disubstituted hexahydropyrimidin-5-yl(phenyl)methanone (products 1-5) were prepared from the reaction of dibenzoylmethane with primary amines and formaldehyde in the presence of Lewis acid catalyst at ambient temperature. Replication of the reaction with acetylacetone and ethyl aetoacetate yielded 1,1′-(1,3-disubstituted hexahydropyrimidine-5,5-diyl)diethanone (products 6-10) and ethyl 5-acetylhexahydropyrimidine-5-carboxylate (products 11-13), respectively. Yields obtained ranged from 69 to 89%.

Disubstituted Alkene | OChemPal

Zarei, One-pot, efficient, and regioselective syntheses of 1,4-disubstituted 1,2,3-triazoles using aryldiazonium silica sulfates in water, Tetrahedron Lett.