Design and synthesis of novel carbazole tethered …

Topoisomerases are the enzymes involved in a number of cellular processes, such as transcription, replication and recombination. The importance of their role in cellular processes can be understood by the fact that they are the target of numerous anticancer agents. They are classified into two types: type I and type II .Topoisomerase which are capable of changing the topology of DNA via transient breaks on one or two of the DNA strands to allow passage of either a single or double DNA strand through the break followed by relegation. There are certain carbazole derivatives such as Strausporine, Adriamycine etc. which inhibit the topoisomerase I significantly and exhibit anticancer activity 4-8.

T1 - Synthesis and photoluminescent properties of new aza-indenofluorene derivatives

Synthesis and electrooptical analysis of polysiloxane and poly-N-vinyl derivatives containing indolyl groups are reported. The indole group and some of its methyl derivatives have been taken into account in order to evaluate their behaviour, with respect to that of the widely employed carbazole group, when used as photoconductive centres attached to a polymer chain. The obtained data show that photoconductivity and traps formation mechanism can be inferred as functions of the physico-chemical parameters (electric dipole moment and ionization potential) of the different groups and polymers involved. To this end such parameters have been carefully computed for a series of pyrrole, indole and carbazole derivatives. The 2,3-dimethylindole derivative appears to be particularly promising due to its electrooptical behaviour in the red absorption region where measurements have been accomplished and are shown to be consistent with the theoretical predictions.


the carbazole derivatives of this invention have the ..

The synthesis of various hetero annulated carbazole derivatives has attracted substantial attention in recent years because there are several naturally occurring compounds that have similar structural frameworks, displaying a wide range of biological activities such as antioxidant, antidiabetic, antimicrobial, anticancer, antitubercular, antipsychotic and anticonvulsant activity 9-17. It has been noticed that introduction of additional heterocyclic rings to the carbazole core tends to exert profound influence in increasing the anticancer activity. We recently investigated and reported the discovery of various carbazole derivatives having potent anticancer properties18-20. With this in mind, we envisaged the design and synthesis of a combination of carbazole with heterocyclic moiety like piperazine and imidazole to obtain therapeutically active anticancer agents.


Synthesis and characterization of heteroatom …

AB - The dual character of benzoquinone is exploited for the synthesis of benzo[a]carbazole derivatives starting from 3-ethylindole derivatives. A diene is generated in situ from the 3-ethylindole derivative with the help of benzoquinone, where it acts as an oxidizing agent. Later it serves as a dienophile and participates in a Diels-Alder reaction with the diene to afford benzo[a]carbazole derivatives.

Disclosed is a process for the preparation of N-alkyl carbazole

N2 - The dual character of benzoquinone is exploited for the synthesis of benzo[a]carbazole derivatives starting from 3-ethylindole derivatives. A diene is generated in situ from the 3-ethylindole derivative with the help of benzoquinone, where it acts as an oxidizing agent. Later it serves as a dienophile and participates in a Diels-Alder reaction with the diene to afford benzo[a]carbazole derivatives.

Synthesis and Properties of 1,3-Indandione …

Conjugated polymers combine the interesting optical and electrical properties of metals with the processing advantages and mechanical properties of traditional synthetic polymers. With clever use of a variety of synthetic tools, researchers have prepared highly pure polymers with optimized physical properties during the past 30 years. For example, the synthesis of well-defined polyacetylenes, polyphenylenes, polythiophenes, polyfluorenes, and other conjugated polymers have significantly improved the performance of these polymeric materials. However, one important class of conjugated polymers was missing from this chemical inventory: easy access to well-defined poly(2,7-carbazole)s and related polymers. This Account highlights advances in the synthesis of poly(2,7-carbazole) derivatives since they were first reported in 2001.

Synthesis and biological evaluation of novel N …

The dual character of benzoquinone is exploited for the synthesis of benzo[a]carbazole derivatives starting from 3-ethylindole derivatives. A diene is generated in situ from the 3-ethylindole derivative with the help of benzoquinone, where it acts as an oxidizing agent. Later it serves as a dienophile and participates in a Diels-Alder reaction with the diene to afford benzo[a]carbazole derivatives.