An early advertisement for Bayer aspirin.

Like most of us, when you experience everyday aches and pains, a bottle of aspirin is probably the first thing you reach for. Yet, while aspirin has been one of the most popular pharmaceutical agents of the past one hundred years, it is actually a synthetic derivative of the natural substance salicylic acid—the associated healing properties of which have been known for millennia.

Therefore, excess amount of NaOH was used to react with acetylsalicyclic acid.

The first recorded use of salicylates dates back about 4,000 years to the Sumerians, who noted the pain remedies of the willow tree on early clay tablets. Ancient civilizations in Mesopotamia used the extract from willow trees to treat fever, pain, and inflammation. Both Chinese and Greek civilizations employed willow bark for medical use more than 2,000 years ago, and the Chinese also used poplar bark and willow shoots to treat rheumatic fever, colds, hemorrhages, and goiter. One of the most noteworthy reports of the use of salicylic acid comes from the father of modern medicine, Hippocrates (460–370 BCE). He recommended chewing on willow-tree bark to patients suffering from fever and pain, as well as the use of a tea brewed from willow bark given to women to lessen pain during childbirth. Around 100 CE the Greek physician Dioscorides prescribed willow bark as an anti-inflammatory agent.


The dissolved mixture on cooling produced white crystals of Aspirin.

Acetylsalicylic acid is prepared from phenol by the following series of reactions:

In the first section, the Synthesis of Aspirin, salicylic acid was weight to be 3.029 grams using mass by difference since it was weighed on a 150 milliliter beaker.


How to Make Aspirin - Acetylsalicylic Acid

History Innovated by the fact that ancient people use willow bark to ease pain, aspirin was first obtained from willow bark by a German chemist called Felix Hoffmann, in 1897....

Synthesis of Aspirin Essay - 1228 Words - StudyMode

The chemical investigation of the healing properties of the substance within the willow bark had already begun in earnest, however, during the early 19th century. This investigation was driven in part by Napoleon’s continental blockade on imports, which affected suppliers of Peruvian cinchona-tree bark (another natural source of salicylic acid). In 1828 Johann Büchner, a professor at the University of Munich, isolated a yellow substance from the tannins of willow trees that he named salicin, the Latin word for willow. A pure crystalline form of salicin was isolated in 1829 by Henri Leroux, a French pharmacist, who then used it to treat rheumatism. In the late 1800s large-scale production of salicylic acid for the treatment of pain and fever was initiated by the Heyden Chemical Company in Germany.

The Synthesis of Aspirin - Michigan Reach Out!

The beginning of aspirin as we know it today dates from the same period when Farbenfabriken vorm. Friedrich Bayer and Company, a dye-manufacturing firm in Germany, began to shift its focus from the dye industry to pharmaceutical production. Because the Bayer Company was already well known, it easily developed brand-name recognition as a pharmaceutical maker. The company’s shift to pharmaceutical production coincided serendipitously with a boom in new pharmaceutical agents, making it seem that a new drug was put on the market almost daily.

Aspirin Synthesis Lab Report by Alissa Lockwood on Prezi

Then they performed another analysis to determine if the use of aspirin before the diagnosis might have modified the association between aspirin post diagnosis, mutation and survival.
They saw that among mutant patients that used aspirin post diagnosis there was a reduction in mortality irrespective of aspirin use before the diagnosis.