Infine Chemicals Co., Limited.--Infine|Infine Chemicals

The reaction of aromatic acrylic acids with thionyl chloride and catalytic amounts of pyridine - the mechanism of this reaction was studied by Krubsack - constitutes a simple and generalizable method for the preparation of 3-chloro-benzo[b]thiophene-2-carboxylic acid chlorides.

12/11/1996 · A process of making 4-chloro-2-thiophenecarboxylic acid, ..
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Condensation of quinoaxaline of 109 with o-phenylene- diamine in the presence of hydrochloric acid gave [4-(1-Benzoimidazol-2-yl)-phenyl]-indolo [2, 3-b] quinoxalin-6-ylmethyl-amine derivatives 110, most of compounds have been identified as Potential Anti-Virus, shown in (Scheme 42).Compound 1b could be selectively reacted with acetic anhydride to provide the mono-acylated adduct in 95% yield and coupling with the α-keto acid as thiophene-2-glyoxylic acid gave - (2-acetylamino- 4- nitro- phenyl) - 2- oxo -2 -thiophen-2-yl-acetamide 111.

Advanced Drugs & Chemical Intermediates,India

5-Chlorobenzo[b]thiophene-2-carboxylic acid | 5-Chloro-1-benzothiophene-2-carboxylic acid, ..
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Some noteworthy developments1818: Brugnatelli isolates alloxan from uric acid.1832: Dobereiner produces furfural (a furan) by treating starch with sulfuric acid1834: Runge obtains pyrrole ("fiery oil") by dry distillation of bones1906: Friedlander synthesizes indigo dye, allowing synthetic chemistry to displace a large agricultural industry1936: Treibs isolates chlorophyl derivatives from crude oil, explaining the biological origin of petroleum.1951: Chargaff's rules are described, highlighting the role of heterocyclic compounds (purines and pyrimidines) in the genetic code.An important feature of the structure of many heterocyclic compunds is that it is possible to incorporate functional groups either as subsituents or as part of the ring itself.