Chloroform was negative in this assay over a range of concentrations (992-23 800 mg/m3 [200-4800 ppm]) that produced large dose-dependent increases in revertants with BDCM.
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These investigators also found significantly depressed thyroxine levels in rats treated with 100 or 200 mg of chlorine dioxide per litre in drinking-water (equivalent to 14 and 28 mg/kg of body weight per day) for 8 weeks.
Each experimental group consisted of 11-12 males and 23-24 females.
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Kidney toxicity after corn oil or aqueous dosing of BDCM (1.5-3 mol/kg of body weight) peaked between 24 and 48 h, as indicated by elevations in kidney weight, urinary N-acetyl-ß-glucosaminidase, ASAT, ALAT, LDH and protein, serum urea and creatinine, and histopathological findings of renal tubule degeneration and necrosis (Lilly et al., 1994, 1997a).
Synthesis of 3-[(acetylamino)(aryl)methyl]-4 …
1.3.4 Haloaldehydes and haloketones Chloral hydrate induces hepatic necrosis in rats at doses equal to or greater than 120 mg/kg of body weight per day.
Preparation of 3-acetyl-4-hydroxycoumarin - …
1.4.3 Adverse pregnancy outcomes Studies have considered exposures to chlorinated drinking-water, THMs or THM species and various adverse outcomes of pregnancy.
7-HYDROXYCOUMARIN Usage And Synthesis:
Using the incidence of kidney tumours in male mice from this study, quantitative risk estimates have been calculated, yielding a slope factor of 4.8 × 10-3 [mg/kg of body weight per day]-1 and a calculated dose of 2.1 µg/kg of body weight per day for a risk level of 10-5.
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intraperitoneal IPCS International Programme on Chemical Safety JECFA Joint FAO/WHO Expert Committee on Food Additives LD50 median lethal dose LDH lactate dehydrogenase LDL low-density lipoprotein LOAEL lowest-observed-adverse-effect level MA 3,4-(dichloro)-5-hydroxy-2(5H)-furanone MBA monobromoacetic acid/monobromoacetate MCA monochloroacetic acid/monochloroacetate MNU methylnitrosourea MOR mortality odds ratio MRI magnetic resonance imaging MTBE methyl tert-butyl ether MX 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone NADP nicotinamide adenine dinucleotide phosphate NOAEL no-observed-adverse-effect level NOEL no-observed-effect level NOM natural organic matter NTP National Toxicology Program (USA) 8-OH-dG 8-hydroxy-2-deoxyguanosine OR odds ratio PAS periodic acid/Schiff's reagent PBPK physiologically based pharmacokinetic model PFBHA O-(2,3,4,5,6-pentafluorobenzyl)-hydroxylamine p Ka log acid dissociation constant PPAR peroxisome proliferator activated receptor PPRE peroxisome proliferator responsive element RR relative risk SCE sister chromatid exchange SD standard deviation SDH sorbitol dehydrogenase SE standard error SGOT serum glutamate-oxaloacetate transaminase SGPT serum glutamate-pyruvate transaminase SMR standardized mortality ratio SSB single strand breaks TBA tribromoacetic acid/tribromoacetate TBARS thiobarbituric acid reactive substances TCA trichloroacetic acid/trichloroacetate TCAN trichloroacetonitrile TCPN trichloropropanone TDI tolerable daily intake TGF transforming growth factor THM trihalomethane TOC total organic carbon TOX total organic halogen TPA 12- O-tetradecanoylphorbol-13-acetate UDS unscheduled DNA synthesis UV ultraviolet UVA254 UV absorbance at 254 nm Vmax maximum rate of metabolism WHO World Health Organization 1.
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A slope factor of 4.2 × 10-3 [mg/kg of body weight per day]-1 (2.4 µg/kg of body weight per day for a 10-5 risk) was derived based on the incidence of large intestine carcinomas in the male rat.