C. Strategy (approach)
Some published syntheses are 40 steps or more! (0.80)40 = 0.013 % ouch!
(Thus one starts with a kilogram of material and ends up with a milligram of material -- if your skill and luck does well that year)
Problems: (1) low overall yield and (2) time consuming both of which cost $$
One way to reduce these problems is by using a convergent strategy
- rather than building the target molecule one piece at a time, two fairly equal sized fragments are built concurrently and then in the last step "tied" together.
overall yield of 11 % (baring any disasters!)
Another advantage is, that if an intermediate is used up then the time (and resources) required remaking this intermediate is considerably less when compared to the linear route.
In our lab, this step will complete a four-step synthesis starting from Benzaldehyde to tetraphenylnaphthalene.
Synthesis of 1,2,3,4-tetraphenylnaphthalene:
Generation of Benzyne:
One of the more famous moments in Bell Labs' synthetic speech research was the sample created by John L. Kelly in 1962, using an IBM 704 computer. Kelly's vocoder synthesizer recreated the song "Bicycle Built for Two," with musical accompaniment from Max Mathews. Arthur C. Clarke, then visiting friend and colleague John Pierce at the Bell Labs Murray Hill facility, saw this remarkable demonstration and later used it in the climactic scene of his novel and screenplay for "2001: A Space Odyssey," where the HAL9000 computer sings this song as he is disassembled by astronaut Dave Bowman.
Synthesis of Aspirin Lab Report Essay Examples
organic lab synthesis
write an equation for a reaction that might form salicylic acid during the workup of the product.
salicylic acid + acetic anhydride under the presence of h2so4—> aspirin and acetic acid