Synthesis of N -Heterocycles - Organic Chemistry Portal

Heterocyclic compounds are of very much interest in our daily life. Heterocyclic compounds have one or more hetero atoms in their structure. They may be cyclic or non cyclic in nature. Heterocyclic compunds have a wide range of application. They are predominantly used as pharmaceuticals, as agrochemicals and as veterinary products. They also find applications as sanitizers, developers, antioxidants, as corrosion inhibitors, as copolymers, dye stuff. They are used as vehicles in the synthesis of other organic compunds. Some of the natural products e.g. antibiotics such as penicillin’s, cephalosporin; alkaloids such as vinblastine, morphine, reserpine etc. have heterocyclic moiety.

Chemistry of heterocyclic compounds : synthesis, reactions and spectroscopy

CONCLUSION: In conclusion, we have developed an exceedingly simple, mild, and clean synthetic method for the synthesis of fused 5-,6-and 7-heterocyclic compounds. In this method, the use of tetraacetylethane and primary amines have been described without using catalysts. Apparently the products obtained by microwave irradiation of starting materals gave high yield without using any organic reagents or solvents.


Bisphosphine-catalyzed mixed double-Michael reactions ..

SYNTHESIS OF HETEROCYCLIC NITROGEN COMPOUNDS BY CLOSURE REACTIONS USING TETRAACETYLETHANE WITH VARIOUS PRIMARY AMINES Abstract

Chlorophyll and heme, which are derivatives pf porphyrin ring system are the components required for the photosynthesis and for oxygen transport in higher plants and in animal. Essential diet ingredients such as thiamin (vitamin B1), riboflavin (vitamin B2), pyridoxol (vitamin B6), nicotinamide (vitamin B3) and ascorbic acid (vitamin C) are heterocyclic compounds.


Synthesis and reactions of imidazoles;

Heterocyclic compunds have a wide range of application: they are predominant among the type of compounds used as pharmaceuticals[5] , as agrochemicals and as veterinary products. They also find applications as sentizers, developers, antioxidants, as corrosion inhibitors, as copolymers, dyestuff 6.They are used as vehicles in the synthesis of other organic compunds.

the synthesis of heterocyclic compounds has ..

In view of the important properties of the heterocyclic compounds as medical agents, we planned to synthesize some new five, six, and seven derivatives, which could possess interesting and useful biological properties.

Heterocyclic Compounds Synthesis Research

I would recommend this book to all scientists who consider working with fluorinated compounds–be they synthetic chemists, life–science chemists, or materials scientists." (, 2010)

"A wealth of information on the types of fluorinated heterocycles that are possible and their methods of synthesis, reactivity, and utilization.