Laursen BS, Sorensen HP, Mortensen KK and Sperling‐Petersen HU (2005) Initiation of protein synthesis in bacteria. Microbiology and Molecular Biology Reviews 69: 101–123.
mTOR is a downstream member of the PI3K/Akt andadenosine monophosphate-activated protein kinase pathways, and is akey regulator of cell growth and metabolism. mTOR () is a component of two similarcomplexes: mTORC1, which promotes mRNA translation and proteinsynthesis by the phosphorylation of ribosomal protein S6 kinase(S6K1) and eIF4E binding protein 1 (4E-BP1) and mTORC2, whichorganizes the cellular actin cytoskeleton and regulates Aktphosphorylation ().
Protein Synthesis Review Flashcards | Quizlet
The serine/threonine kinase Akt, also known asprotein kinase B or PKB, with three isoforms (Akt1, Akt2 and Akt3),plays a critical role in regulating diverse cellular functions() including cellsize/growth, proliferation, survival, glucose metabolism, genomestability, transcription and protein synthesis, andneovascularization (). One of themajor functions of Akt/PKB is to promote growth factor-mediatedcell survival, to promote cell proliferation and to inhibitapoptosis through the inactivation of pro-apoptotic proteins, suchas Bad (Bcl-2 antagonist of cell death) and mouse double minute 2homolog (MDM2; which causes the degradation of p53) ().