Molecular Biology Protein Synthesis MCAT Review and MCAT Prep

Laursen BS, Sorensen HP, Mortensen KK and Sperling‐Petersen HU (2005) Initiation of protein synthesis in bacteria. Microbiology and Molecular Biology Reviews 69: 101–123.

DNA, RNA, DNA Replication, Protein Synthesis and Mutations Review Game!

mTOR is a downstream member of the PI3K/Akt andadenosine monophosphate-activated protein kinase pathways, and is akey regulator of cell growth and metabolism. mTOR () is a component of two similarcomplexes: mTORC1, which promotes mRNA translation and proteinsynthesis by the phosphorylation of ribosomal protein S6 kinase(S6K1) and eIF4E binding protein 1 (4E-BP1) and mTORC2, whichorganizes the cellular actin cytoskeleton and regulates Aktphosphorylation ().

Protein Synthesis Review Flashcards | Quizlet

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The serine/threonine kinase Akt, also known asprotein kinase B or PKB, with three isoforms (Akt1, Akt2 and Akt3),plays a critical role in regulating diverse cellular functions() including cellsize/growth, proliferation, survival, glucose metabolism, genomestability, transcription and protein synthesis, andneovascularization (). One of themajor functions of Akt/PKB is to promote growth factor-mediatedcell survival, to promote cell proliferation and to inhibitapoptosis through the inactivation of pro-apoptotic proteins, suchas Bad (Bcl-2 antagonist of cell death) and mouse double minute 2homolog (MDM2; which causes the degradation of p53) ().