The structural formulas of levofloxacin, the key intermediates and semi-products ofits pilot-scale synthesis preformed in the Postovsky Institute of Organic Synthesis,UB RAS, are presented in .
Currently, in the Postovsky Institute of Organic Synthesis, UB RAS, the design andsynthesis of new fluoroquinolone derivatives and their analogs with antibacterialactivity are in progress. An important constituent of these studies is theinvestigation of the interaction of new compounds with DNA gyrase, which may beconsidered among the criterion for the purity of levofloxacin. In this paper, wepresent results of the investigation of the interaction of DNA gyrase with newfluoroquinolone derivatives, as well as with levofloxacin samples from the pilotbatch.
Postovsky Institute of Organic Synthesis Ural …
The LC/MS group acts as a part of a Joint-Use Center of the Ural Branch of RAS established in the Postovsky Institute of Organic Synthesis UB RAS