AB - Sodium polyaspartate (PAspNa) derivatives with vinylbenzyl pendant groups (VBA-PAspNa) were synthesized by reaction of poly(succinimide) (PSI) and vinylbenzylamine (VBA), and hydrolysis by sodium hydroxide (NaOH) solution. VBA-PAspNa is a macromonomer with multiple vinyl groups in the side chain. Submicron sized polymeric particles were prepared by dispersion copolymerization of styrene with VBA-PAspNa in a mixture of ethanol and water. Particle diameter decreased with increasing concentration and vinyl group fraction of VBA-PAspNa. When compared with the particle diameter prepared using PAspNa or benzylamine-modified PAspNa (BA-PAspNa) as a dispersion stabilizer without vinyl groups, the particles prepared with VBA-PAspNa were an order smaller than those prepared with PAspNa or BA-PAspNa. The particles after refinement show an adequate negative ζ-potential. From this result, we clarified the presence of PAspNa chains anchored onto the particle surface.
T1 - Heterogeneous polymerization with polyaspartate macromonomer having vinyl pendant groups. I. Synthesis of macromonomer and dispersion copolymerization of styrene
Synthesis of Thermal Polyaspartate.
Metallothionein synthesized within the kidney protects from cadmium toxicity, but intravenously injected cadmiummetallothionein is more nephrotoxic than inorganic cadmium (see section 4.5.3.).