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Sibling studies support a genetic contribution and heritability of greater than 50%. The number of implicated genes currently stands at 200-1,000, but none is specific for autism (,). Furthermore, there is a high, 10-50%, discordance among monozygotic twins (). This suggests that other modifying factors might influence the clinical outcome. Proximate modifying factors, for example abnormal DNA methylation, have been reported but the ultimate underlying factor is yet to be identified. Thus, at present, ASD is defined by a wide spectrum of symptoms but not by the cause.

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An hypothesis is the outcome of the postulate, signifying a cognitional convergence and readiness for testing of the convergence with as wide a range of experience as possible.


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Origin of hypothesisGr, groundwork, foundation, supposition from hypotithenai, to place under from hypo-, under + tithenai, to place: see hypo- and do