Nonribosomal peptide - Wikipedia

Figure 1: Modular organisation of NRPS.Non-ribosomal peptide synthetases can be subdivided in modules each incorporating one amino acid. Those are comprised of several different domains, here condensation (C), adenylation (A) and thiolation (T) (according to [13]).

These peptides are synthesized by non-ribosomal peptide synthetases (NRPS).

11. Caboche S, Leclere V, Pupin M, Kucherov G, Jacques P (2010)Diversity of monomers in nonribosomal peptides: towards the predictionof origin and biological activity. J Bacteriol 192: 5143–5150.


Non Ribosomal Peptides - YouTube

Mootz (1997), Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis, Chem.

25. Schwarzer D, Mootz HD, Linne U, Marahiel MA (2002) Regenerationof misprimed nonribosomal peptide synthetases by type IIthioesterases. Proc Natl Acad Sci USA 99: 14083–14088.


Non-Ribosomal Peptide Synthetases of Fungi | …

...ynthetic mechanisms of lichenysin production. The structural similarity of lichenysins and surfactin suggests that the peptide moiety is produced nonribosomally by multifunctional peptide synthetases =-=(7, 13, 25, 49, 53)-=-. Peptide synthetases from bacterial and fungal sources describe an alternative route in peptide bond formation in addition to the ubiquitous ribosomal pathway. Here, large multienzyme complexes affec...

Team-sequoia:Non-ribosomal peptide synthesis

Definition of Non-Ribosomal Peptides: A class of peptide secondary metabolites synthesized from proteinogenic or non-proteinogenic amino acid monomers, by large multifunctional proteins called nonribosomal peptide synthetases (NRPS).

Centre for Natural Non-Ribosomal Peptide Synthesis - AU

27. Patel HM, Walsh CT (2001) In vitro reconstitution of thePseudomonas aeruginosa nonribosomal peptide synthesis of pyochelin:characterization of backbone tailoring thiazoline reductase andN-methyltransferase activities. Biochemistry 40: 9023–9031.

Biosynthesis of Nonribosomal Peptides | Annual Review …

...stins are known to date. Microcystins are synthesised by the thiotemplate mechanism like other non-ribosomal peptides (i.e. antibiotics such as gramicidin or tyrocidin) produced by bacteria and fungi =-=[22]-=-. The large enzyme complex encoded by the mcy gene cluster is composed of peptide synthetases, polyketide synthases and tailoring functions for microcystin biosynthesis. It has a modular structure, ea...

Non-Ribosomal Peptide Synthetases - Marahiel, …

Cyanobacteria are a very old group of prokaryotic organisms that produce very diverse secondary metabolites, especially non-ribosomal peptide and polyketide structures.