Botched LSD synthesis- psychoactive byproducts? : LSD

LSD is one of the most powerful hallucinogenic drugs known. It was invented in 1938 by the Swiss chemist, Albert Hoffman, who was interested in developing medicines from compounds in , a fungus that attacks rye. Although LSD is purely synthetic, clues to its biological activity can be found by tracing the history of the fungus from which it is derived.

Introduction to Lysergic acid Diethylamide LSD e ba f b fa f b eb c World News

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The underground mastermind of psychedelic cookery has come up with even more ground-breaking techniques for those who study the craft. Practical LSD Manufacture provides the most detailed, comprehensive and concise description ever of several of the methods employed in the preparation of lysergic acid diethylamide, or LSD, from natural sources! Uncle Fester also offers a breakthrough in the literature of psychedelic chemistry: a simple process for extracting the hallucinogenic drug TMA-2 from the commonly found and easily grown calamus plant.

Practical LSD Manufacture contains:

- Natural sources of the lysergic amides, including harvesting procedures for ergot-infested rye and Spartina marsh grasses
- Methods of extraction and isolation of the lysergic acid amides
- An interpretation of LSD-progenitor Albert Hofmann's patented "one-pot shot" method of LSD synthesis, plus purification and storage techniques
- A never-before-published presentation of "Method X," wherein a propionic anhydride mixes with lysergic acid, allowing for a much-improved synthesis
- A section on solvent management, a crucial but often overlooked detail all chemists should be aware of
- New recipes which further enable the clandestine operator to lower his or her profile
- And much, much more
- Remember: Practical LSD Manufacture is sold for informational purposes only.

Sep 13, 2007 · if only lsd for dummies existed

However, the fact that LSD is an antagonist to 5-HT2 receptors specifically makes this conclusion problematic.

So, in the spring of 1943, he repeated the synthesis of LSD-25. Quoted below is his entry for this experiment in his laboratory journal of April 19, 1943.

LSD psychedelic trip. - The Third Wave

Mescaline, being a phenylethylamine derivative, is structurally related to the neurohumoral transmitters norepinephrine and epinephritic. LSD, and the constituents of ololiuqui as well as the active principles of the hallucinogenic mushrooms psilocybin and psilocin, are indoles, more precisely tryptamine derivates, like the neurohumoral factor serotonin. Because of this structural relationship between the hallucinogens and norepinephrine and serotonin, it is probable that the psychotomimetic activity is due to an interaction between these substances in the metabolism of the central nervous system. Investigation of the relationships between endogenous neurohumoral factors and hallucinogens is a rewarding facet of psychopharmacological research.
As I am a chemist, I have mainly discussed the chemical, phytochemical and historical aspects of the discovery of LSD and the investigation of naturally occurring hallucinogens. Needless to say, this audience attaches primary importance to the pharmacological and clinical effects, which make LSD and the other specific hallucinogens a valuable tool in experimental psychiatry and a valuable drug aid in psychoanalysis and psychotherapy. Another aspect of the hallucinogens and especially of LSD with enormous social impact is of course the paramedical use and the misuse of these substances. But this very complex problem would provide material for a special lecture, or indeed for a series of such lectures.
The aim of my chapter is to describe an unusual cycle of chemical research, full of coincidences, a kind of magic circle, which started with the synthesis of various Iysergic acid amides and the discovery of the extraordinary psychotomimetic potency of Iysergic acid diethylamide (LSD), which led to the investigation of the sacred Mexican mushrooms, the isolation of psilocybin, and ended with ololiuqui, where lysergic acid amides were again encountered, thus closing the magic circle.

10/11/2017 · CLARKSVILLE, Tenn

The main constituents of ololiuqui, i.e., the seeds of are lysergic acid amide and lysergic acid 1-hydroxyethylamide. The active constituents of ololiuqui are very closely related to LSD. The only difference between the main constituent of ololiuqui, Iysergic acid amide, and LSD is that the two hydrogen atoms of the amide are replaced by two ethyl radicals. It is a very significant one with regard to the psychotomimetic activity. The ololiuqui principle, Iysergic acid amide, is much less active than Iysergic acid diethylamide (LSD), and provokes psychic symptoms qualitatively different from those of LSD, as will he shown later.