A thorough search for high cycle fatigue (HCF) tests ..

In relation to the hypoglycemic problems - my blood sugar levels have been quite low from the onset of my symptoms. People with chronic fatigue syndrome have impaired glucose tolerance and have a higher than normal lactic acid level. In fact, there was talk of a diagnostic test for CFS based on lactic acid serum levels.

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My 16 year old daughter was diagnosed with GS early on this year. This was after many months and dozens of blood tests and examinations. One doctor said that she thought she also had ME. My daughter had terrible fatigue, memory lapses, lack of concentration, severe stomach pains and headaches, yellow eyes, - the list goes on and on... We can always tell when a bad episode is going to happen. Her eyes become more yellow than normal and her skin is very pale. Her latest bout has lasted for about 2 weeks. For the first time she has been pysically sick instead of the usual terrible nausea. Painkillers and anti-inflammatery drugs dont work... Think we have found out why she has been so ill for the last couple of weeks. It looks like she has been worse 'cos of antibiotics she has been taking. They should not have been taken 'cos they are bad for the liver.

Low cycle fatigue of FPSO ship structure: Authors ..

Surprisingly, low cycle fatigue beinga border phenomenon between the aforementioned failure phenomena, is oftennot considered.

Low cycle corrosion fatigue is an interesting issue in civil Engineering because it may effect the lifetime of structures in negative and unexpected ways. However, analysis of design codes has revealed that low cycle corrosion fatigue is not a major issue in the design of offshore structures because these structures are designed with a global elastic philosophy. This means that the number of cycles that a structure can withstand usually stays well within the high cycle range. The joints ( welded or otherwise ) revealed to be the less resistant elements to low cycle corrosion fatigue. Furthermore, it was revealed that in the ultra low cycle region the effect of the environment is heavily reduced. It was also revealed that the effect of cathodic protection is strongest in the upper spectrum of the high cycle range and deteriorates in the lower spectrum of the high cycle range. It was also revealed that a structure in air and a structure in seawater with cathodic protection have essentially the same fatigue resistance when in the ultra low cycle range. In the ultra low cycle range, the problem appears to turns into mostly a low cycle fatigue problem. In the ultra high cycle region the problem appears to turns into mostly a corrosion problem. S-N curves that can predict the low cycle fatigue life of structures in a deleterious environment are very rare. The only S-N curve available that can be used for structural steel subjected to low cycle corrosion fatigue is one for tubular sections. However, Mathematical modeling based on regression and a principle of constant slopes in a fatigue cycle region ( low cycle, high cycle, ultra high cycle ) has made it possible to not only calculate the low cycle corrosion fatigue life of tubular joints but the low cycle corrosion fatigue life of other types of joints as well.

high-stress amplitude low cycle fatigue of a material ..

Dr. Robert Suhadolnik, at Temple University, showed as far back as 1989, that activity in this pathway was upregulated in patients with chronic fatigue syndromes. Crucially in 1996 it was also noted that a proportion of patients had an abnormal version of the RNase L enzyme. This low molecular weight form is 37 kDaltons, compared with the normal 80 and 47 kDalton versions. It was thought initially that all chronic fatigue patients had this abnormal form. The most recent figures I could find by Dr. K De Meirleir showed that the low molecular weight version was found in 680 out of 705 patients. The levels quantitatively vary though, and the amounts correlate with the Karnofsky Disability Index. The low molecular weight RNase L enzyme is up to six times more biologically active and resists protein degradation. Therefore when expressed, patients suffer an even greater depletion of ATP reserves and inhibition of protein synthesis. It has been suggested that mycoplasma genus cause the splitting of Rnase L.

Low Cycle Fatigue in Abaqus - PolymerFEM - Constitutive …

In Short: The RNase L anti-viral enzyme is upregulated in CFS. 680 out of 705 patients had an abnormal low-weight version of the RNase L enzyme. This enzyme is 6x more biologically active. Therefore when expressed, patients suffer an even greater depletion of ATP reserves and inhibition of protein synthesis. The overwhelming fatigue with an acute viral illness is due in part to ATP depletion in order to fuel anti-viral pathways. It has been suggested that mycoplasma genus cause the splitting of Rnase L. It is also found that the RNase L inhibitor is low in patients with CFS (569 as opposed to 2296), which may be the reason for the upregulation. Environmental pollutants can also activate this antiviral pathway. This upregulated system can then cause problems to varying degrees with enzymatic detoxification pathways, particularly in the liver. It can monopolise protein synthesis and deplete essential nutrients such as glutathione. Low white cell glutathione is a feature of treatment resistant patients. 20-47% of CFS sufferers have severe multiple chemical sensitivity. These sensitized pathways respond unfavorably to exposure to volatile organic compounds and pesticides, reacting from low doses similarly to normal people reacting from high levels of exposure.

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These patients were from a total of 45 men referred with chronic fatigue syndrome. Therefore 16% of this population had Gilbert's syndrome, which compares with 2% in the general population. All 7 were referred to our fatigue clinic and met the Oxford criteria for chronic fatigue syndrome. The fatigue was severe, had been present for at least 6 months, and was incapacitating. They had no conditions known to produce chronic fatigue. Liver function and gamma-glutamyltransferase concentrations were normal. There was no evidence of haemolysis.