The laboratory preparation of DDT

Behavioural tests on adults at 4 months of age indicated disruption of habituation in mice treated on postnatal day 10. Habituation was defined as a decrease in locomotion, rearing, and total activity variables in response to diminishing novelty of the test chambers over a 60-min test period divided into three 20-min periods, with 12 animals in each group. The effects of DDT on behaviour and muscarinic cholinergic receptors in adult mice were not observed when DDT was administered to mice on postnatal day 3 or 19 and therefore appeared to be limited to a short induction period during neonatal development at about day 10. As the responses reported from this laboratory were found after administration of a single low dose of DDT to mice of one strain, exclusively when treated on postnatal day 10, their relevance to the consequences of exposure of humans to DDT remains to be determined (Eriksson, 1984; Eriksson & Nordberg, 1986; Eriksson et al., 1990, 1992; Johansson et al., 1995).

DDT was first synthesized in 1874 by a young German chemistry student, Othmar Zeidler.

This compound presented special challenges in purification; the final, successful procedure is outlined and a video showing the deflagration is available.
A nitrated simple sugar, capable of deflagration from flame and detonation from impact.
Nitroglycerine synthesis: One of the first high explosives ever created, it still finds a lot of uses as dynamite in mining and road construction.
A chemical very similar to TNT, found in most laboratories nowadays, useful as a dye, or as a starting base for metal picrates such as those found in the L.E.

Synthesis of DDT with Chlorosulfonic Acid as Condensation Agent.

(1971) Laboratory studies on the uptake of dieldrin andDDT by earthworms.

Video of combustion available.
A PowerLabs exclusive; chemically similar to Picric Acid, but more reactive and prone to initiation, this is the starting chemical for the synthesis of Lead Styphnate, the number one priming compound used nowadays.

Zinc Oxide—From Synthesis to Application: A Review - MDPI

Lal & Saxena (1980) reported that DDT did not affect growth and DNAsynthesis in the ciliate Stylonychia notophora at concentrations of1 mg/litre or less.

Sam Barros' CHEMLABS! Chemistry in action! - PowerLabs

Cole & Plapp (1974) found inhibition of growth and photosynthesisof the green alga Chlorella pyrenoidosa with DDT at 1 µg/litre in themedium.

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(1972) showed that DDT, at concentrationsbetween 9.4 and 1000 µg/litre, reduced photosynthetic carbonfixation and the cell content of chlorophyll a relative to controlsin a marine diatom Nitzschia delicatissima , over a 24-h period.

Lab Assignments - Nazareth College

TOXICITY TO MICROORGANISMSAppraisal Aquatic microorganisms are more sensitive than terrestrial ones to DDT. An environmental exposure concentration of 0.1 µg/litre can cause inhibition of growth and photosynthesis in green algae. Repeated applications of DDT can lead to tolerance in some micro- organisms. There is no information on effects concerning the species compo- sition of microorganism communities.

DDT (dichlorodiphenyltrichloroethane) - humans, body, …

Numerous studies have been conducted on the effect of DDT on the immune system of laboratory animals. Because no validated study protocols were used in different species, at different doses, application periods, and routes of exposure, and with evaluation of different parameters, a reliable NOAEL could not be stimated for effects on the immune system.