Beadle, a geneticist, initially worked with the fruit fly Drosophila in the laboratory of Thomas Hunt Morgan at Columbia University. By 1935 he had developed suggestive evidence that eye color, known to be inherited, represents a series of genetically determined chemical reactions. His work over the next six years, much of it with Edward L. Tatum, a biochemist, furthered this hypothesis. But the complexity of Drosophila proved a drawback to developing experiments that would demonstrate a link between specific genes and their chemical products.
This experiment was based on the 1928 experiment of Griffith where he showed that some substance from dead IIIS bacteria (S cells have a capsule) could transform live IIR bacteria (R cells lack a capsule) into live IIIS cells.
Discovery of DNA Discovery of DNA Frederick Griffith …
Morgan's experimental and theoretical work inaugurated research in genetics and promoted a revolution in biology. Evidence he adduced from embryology and cell theory pointed the way toward a synthesis of genetics with evolutionary theory. Morgan himself explored aspects of these developments in later work, including Evolution and Genetics published in 1925, and The Theory of the Gene in 1926. He received the Nobel Prize in Physiology or Medicine in 1933.