Biosynthesis and release of beta-endorphin-, N-acetyl …

This new active ingredient is based on an extract of monk’s pepper berries (Vitex agnus-castus) which was found to stimulate the synthesis of DHEA and to possess a beta-endorphin-like activity.

T1 - Design and Synthesis of a Model Peptide with β-Endorphin-Like Properties

(1986) found that multiple administrations of methamphetamine in the striatal serotonergic system on rats was partially related to the increased activity of dopamine receptors, in particular, the D1type.


Glucocorticoids inhibit endorphin synthesis by pituitary …

T1 - Interaction among beta-endorphin, nitric oxide and prostaglandins during ovulation in rats

First synthesis of a nonacosapeptide corresponding to the entire amino acid sequence of salmon endorphin, Ac-Tyr-Gly-Gly-Phe-Met-Lys-Pro-Tyr-Thr-Lys-Gln-Ser-His-Lys-Pro-Leu-Ile-Thr-Leu-Leu-Lys-His-Ile-Thr-Leu-Lys-Asn-Glu-Gln-OH, and its des-acetyl derivative was described. Toward the synthesis of this hormone, five fragments, 1-7, 8-15, 16-18, 19-24 and 25-29, were prepared and the fragments were served as the building blocks for the final construction of the entire amino acid sequence of the hormone. The final deprotection of the fully protected peptide was achieved by treatment with trifluoroacetic acid and the purification of the synthetic peptides was effected by a column chromatography on CM-cellulose and then Sephadex LH-20. The synthetic acetylated nonacosapeptide was compared with purified natural salmon endorphin by means of chromatography, electrophoresis and also enzymatic digestion and found to be indistinguishable from natural isolated salmon endorphin. The opiate activity of the synthetic salmon endorphin and des-acetyl salmon endorphin was also described.


Beta-endorphin | definition of beta-endorphin by …

1. b-endorphin: The pre-propeptide, pre-proopiomelano-cortin, is synthesized in rough endo-plasmic reticulum of neurons in the anterior pituitary, in the intermediate lobe of pituitary, and in the arcuate nucleus of hypotha-lamus. Removal of a signal peptide from the pre-propeptide within the rough endoplasmic reticulum results in the generation of the propeptide proopi-omelanocortin, which is then transported to the Golgi apparatus where it is packaged into vesicles. These vesicles are transportevd to the axon terminal by fast axonal transport. Further proteolytic processing in the terminal results in the generation of the active peptides, adrenocorticotropic hormone (ACTH) and P-lipotropin. P-lipotropin is further cleaved into y-lipotropin and P-endorphin (31-amino acid C-terminal fragment). The term "endorphin" refers to a substance that has morphine-like properties. P-endorphin-containing neurons are located in the hypothalamus and send projections to periaqueductal gray (PAG) and noradrenergic cells in the brainstem.

beta-endorphin explanation free

Althoughit has recently been shown9 that dexamethasone inhibits invivo elevation of the content of pituitary endorphins afteradrenalectomy, the mechanism of the action of this syntheticglucocorticoid remains unclear.

Synthesis of human β-endorphin - Free Patents Online

Recent results have indicated that β-endorphin andadrenocorticotropic hormone (ACTH) are synthesised by pituitary cellsfrom a common precursor polypeptide5-8 and that they bothappear in the circulation after stressful stimulation9.

Endorphin - definition of endorphin by The Free Dictionary

This finding has further support in other research that has found that blocking dopamine synthesis prevents serotonin degeneration (Schmidt et al., 1985).