Intermediate for use in docetaxel synthesis and …

A novel therapy based on programed death 1 (PD-1)/programed death ligand 1 (PD-L1) inhibitors showed an increasing potential in several malignancies including advanced NSCLC.
OBJECTIVES: This article is a meta-analysis aiming to systematically evaluate the efficacy and safety profiles of PD-1/PD-L1 agents in patients with NSCLC.
DATA SOURCES: Data were collected from eligible studies searched from PubMed, ScienceDirect, and Web of Science.
SYNTHESIS METHODS: Pooled hazard ratio (HR) for overall survival (OS) and progression-free survival (PFS) was estimated to assess the efficacy of PD-1/PD-L1 inhibitors versus docetaxel, pooled odds ratio (OR) was calculated for objective response rate (ORR).

T1 - Template synthesis of PMAA@chitosan hollow nanorods for docetaxel delivery

Docetaxel, a semi-synthetic second-generation taxane, can slow down the progression of prostate cancer, and it retains antitumor activity in CRPC patients [].


AB - Nanorods are capable of enhanced intracellular delivery and prolonged blood circulation over their spherical counterparts, and thus can be used as unmatched drug carriers for cancer chemotherapy. An innovative method was developed to synthesize size-tunable, PMAA@chitosan-based, hollow polymeric nanorods for intracellular delivery, by using mesoporous silica nanorod templates. The morphology of the polymeric hollow nanorods was examined by TEM and FT-IR spectra, which indicated a homogeneous three-dimensional structure. An uptake study using human lung carcinoma A-549 cell lines revealed highly efficient cell internalization of the FITC-labeled nanorods, suggesting the potential of utilizing these nanorods as carriers in achieving effective intracellular drug delivery. Cell viability studies of the docetaxel-loaded nanorods yielded consistent results, as the drug-loaded nanorods produced a significantly higher inhibition of the growth of A-549 tumor cells when compared with treatment by free docetaxel. Overall, this preliminary in vitro investigation sheds light on the use of prepared hollow polymeric nanorods for drug delivery applications.

Docetaxel | C43H53NO14 | ChemSpider

The synthesis and in vitro evaluation of four novel 3-azidobenzoyl photoaffinity analogues of paclitaxel and docetaxel is detailed. Due to their good to excellent ability to stimulate the assembly of microtubules they have potential as photoaffinity probes.

Docetaxel Trihydrate - InvivoChem

Dendrimers are synthetic nanocarriers that comprise a highly branched spherical polymer as new, efficient tools for drug delivery. However, the fate of nanocarriers after being internalized into cells has seldom been studied. Docetaxel loaded dendritic copolymer H40-poly(D,L-lactide) nanoparticles, referred to as “DTX-H40-PLA NPs”, were prepared and used as a model to evaluate whether the NPs were sequestered by autophagy and fused with lysosomes. Besides being degraded through the endolysosomal pathway, the DTX-loaded H40-PLA NPs were also sequestered by autophagosomes and degraded through the autolysosomal pathway. DTX-loaded H40-PLA NPs may stop exerting beneficial effects after inducing autophagy of human MCF-7 cancer cells. Co-delivery of autophagy inhibitor such as chloroquine and chemotherapeutic drug DTX by dendritic copolymer NPs greatly enhanced cancer cell killing , and decreased both the volume and weight of the tumors in severe combined immunodeficient mice. These findings provide valuable evidence for development of nanomedicine such as dendritic copolymer NPs for clinical application.


Jinhe, is able to provide many kinds of side-chains for synthetic of Palitaxel and docetaxel, mainly including (2R,3S)-3-Phenylisoserine Hydrochloride(2R,3S)-N- benzoyl-3-Phenylisoserine Methyl Ester (2R,3S)-N-tert-butoxycarbonyl-3-Phenylisoserine Methyl Ester etc.