, p. 458) look at the genealogy of the hypothesis shows that it has been absorbed within the behavioural model, as recent DOHaD research has shifted the focus from social determinants to ‘the interior of women's bodies’, framing women as responsible for the ‘transmission’ of obesity through generations (). Likewise, the need for engagement is urgent, as some social scientific knowledge is being swept into the war on obesity. For example, finds that shifts in focus to obesogenic environments implicates geographers in the politics of obesity, a point inadequately addressed by the discipline. Obesity is already being framed as an issue of environmental justice (see ; ), yet critical geographies must go beyond describing obesogenic environments to critically examining how obesity is experienced in materialising spatiotemporal contexts (; ). Evans suggests that a lack of engagement with the temporal dimensions of fat, which as noted is found in the Barker hypothesis, means that a critical politics of risk for obesity is not being developed.
It is a commonly held belief that infiltration of immune cells into tumor tissues and direct physical contact between tumor cells and infiltrated immune cells is associated with physical destructions of the tumor cells, reduction of the tumor burden, and improved clinical prognosis. An increasing number of studies, however, have suggested that aberrant infiltration of immune cells into tumor or normal tissues may promote tumor progression, invasion, and metastasis. Neither the primary reason for these contradictory observations, nor the mechanism for the reported diverse impact of tumor-infiltrating immune cells has been elucidated, making it difficult to judge the clinical implications of infiltration of immune cells within tumor tissues. This mini-review presents several existing hypotheses and models that favor the promoting impact of tumor-infiltrating immune cells on tumor invasion and metastasis, and also analyzes their strength and weakness.
The fetal origins hypothesis ..
Science and medicine participate integrally in the marginalisation of fat people in the war on obesity. However, resources for critical examination of obesity are also found in science. This article contributes to the mobilisation of scientific knowledge for critical understandings of obesity by exploring the Barker hypothesis.
In Memoriam: David Barker, M.D., Ph.D., FRS | The …
A more recent example is taken from a newsletter from Partners for Better Oral Health, a coalition of fluoride promoters located in Harrisburg, Pennsylvania.
In Memoriam: David Barker, M.D., Ph.D., FRS
Tetsu Maruyama, CSO of the DDF, said: “The DDF has a unique approach and this first year of investing has shown clearly how our new way of focusing investment and deploying an expert team can unlock areas of dementia research that would otherwise be underdeveloped or unacknowledged. We draw on the combined expertise of our network and collaborate creatively with researchers, entrepreneurs, investors, charities and industry. The fact that, in addition to investing in established businesses, we are willing and able translate ripe, investible science through translational projects, company formation and our establishment of Entrepreneurs-in-Residence is particularly critical in meeting what is a huge and growing global challenge.”
Professor David Barker - Telegraph
DDF’s investment in Alector reflects the team’s belief that there is a significant opportunity to develop dementia drugs targeting biological pathways beyond the prevailing amyloid beta hypothesis. It has an initial portfolio of 12 investments in drug discovery companies and projects targeting areas including microglial biology and inflammation, mitochondrial dynamics, trafficking and membrane biology and synaptic physiology and function.
The thrifty phenotype hypothesis - OUP Academic
Roman philosopher and playwright. In AD 49 Seneca, a Spanish-born scholar was chosen to become the tutor of future emperor Nero. Seneca spent the major portion of his life studying and writing and instructing his disciple Nero on the art of government and the virtues of a stoic philosopher-king. When the young prince ascended the imperial throne in AD 54, Seneca remained his most trusted advisor and three years later, in 57, was honored by the conferral of consulship. However, Seneca lost favor with the emperor and prudently withdrew from imperial politics and court society in 62. In 65 he was implicated in Piso's conspiracy to assassinate Nero and was commanded by his onetime pupil to kill himself. With Stoic composure, the philosopher has his veins opened and bled to death....... £45.00