Laboratories in many places, notably throughout the USA, are engaged in clandestine manufacture of methamphetamine. The chemistry is well understood, and widely published, notably on the web, though not easy to achieve. It is the synthesis of methamphetamine that is illegal. Two methods that have been described both involve the reduction of ephedrine (itself readily available) using either lithium in liquid ammonia as the reducing agent, or else red phosphorous and iodine to generate HI for the reduction.
Most of the methamphetamine abused in the United States is produced in so-called superlabs, many of which are located in Mexico. However, methamphetamine is relatively easy and inexpensive to synthesize, and small-scale illicit production occurs in home kitchens, workshops, recreational vehicles, and rural cabins.[4, 49, 54] Instructions for synthesis can be found on the Internet and the precursors are not difficult to obtain.
Synthesis of Methamphetamine by the Leuckart Method - YouTube
A common method of synthesis begins with ephedrine, which is reduced to methamphetamine using hydriodic acid and red phosphorus. Alternative approaches include using a different acid, a different catalyst, or a substituted ephedrine (eg, chloroephedrine, methylephedrine). The federal government and some states have enacted laws decreasing the availability of necessary precursor chemicals such as ephedrine, but many of these agents can still be obtained in other countries.
Aesthetic Reconstruction of “Meth Mouth” | Dentistry …
It involves placing pseudoephedrine crushed tablets into a container with ammonium nitrate, water and a hydrofobic solvent. Then a hydrogen cloride gas is used to recover crystals for purification.
The easiness of the processe make it popular in the latest years and it's notorious for causing burns.
Synthesis of N -Methylamphetamine – Part of The …
Also known as "nazi method", consists in reacting pseudoephedrine with anhydrous ammonia and alkali metals like lithium or sodium. The reaction is allowed to stand until the ammonia is evaporated. This method is more dangerous because of the reactivity of the alkali metals and ammonia.
Synthesis of N-Methylamphetamine
's production begin with either Phenyl-2-Propanone (P2P) or with ephedrine or pseudoephedrine. The principal methods used are the Nagai method, Birch's reduction or the semplifyed shake'n'bake.
and agents that affect the synthesis ..
The maximum conversion rate for ephedrine and pseudoephedrine is 92%, although typically, illicit methamphetamine laboratories convert at a rate of 50% to 75%.Most methods of illicit production involveof the Hydroxylgroup on the ephedrine or pseudoephedrine molecule.
amphetamine but greater than that of ephedrine
was first made in 1887 in Germany and methamphetamine, more potent and easy to make, was developed in Japan in 1919; it went into wide use during the to keep the troops awake. The japanese kamikazes use it before their suicidal missions.
In 1950's, amphetamine was prescribed as a or to cure .
In 1980, (phenyl-2-propanone, a precursor for amphetamine) was placed under federal control, so was discovered that, using the , readily available, you can obtain a drug twice as strong as the -derived one, and it is not amphetamine, methamphetamine indeed.