Gene transfer methods are promising in the field of gene therapy. Current methods for gene transfer include three major groups: viral, physical and chemical methods. This review mainly summarizes development of several types of chemical methods for gene transfer and by means of nano-carriers like; calcium phosphates, lipids, and cationic polymers including chitosan, polyethylenimine, polyamidoamine dendrimers, and poly(lactide-co-glycolide). This review also briefly introduces applications of these chemical methods for gene delivery.
Reference various chemical and physical characteristics of our polymers from lactide, glycolide and ε-caprolactone to assist you in selecting the optimal polymer for your program.
Chemical syntheses of biodegradable polymers
Synthetic polymers, which includes the large group known as , came into prominence in the early twentieth century. Chemists' ability to engineer them to yield a desired set of properties (strength, stiffness, density, heat resistance, electrical conductivity) has greatly expanded the many roles they play in the modern industrial economy.
Synthesis of biodegradable addition polymers
The majority of biobased or biodegradable polyesters are completely aliphatic. They usually have a low melting point and glass transition temperature and poor hydrolytic stability, that is, they are rather hydrophilic and, therefore, will have a moderate to high water uptake when exposed to moisture. This will effect the mechanical properties and stability. For this reason, some biodegradable polymers have been blended with more stable polymers or have been copolymerized with aromatic building blocks (aromatic acids or anhydrides). For example, poly(butylene adipate-co-terephthalate) (PBAT) is commercially synthesized from adipic acid, terephthalic acid, and 1,4-butane diol.
3.4.5 Bio-based and Biodegradable Polymers 63
Fatty acids have been used previously in the development of polymers for biomedical applications as they are considered to be inert, inexpensive and biocompatible, as well as possessing low toxicity. This review focuses on use of different fatty acids for synthesis of injectable polymers for intended use as drug carriers.
Handbook of Biodegradable Polymeric Materials and …
An important property of biodegradable polyesters is the degradation time, which should be as short as possible in regard to disposal. However, corrosion resistance might decrease too strongly when the polymer has a very short degradation time. Depending upon the polymer and the conditions, degradation times will range from several months to several years.
Handbook of Biodegradable Polymeric Materials ..
This chapter will deal mostly with synthetic polymers, but will include a synopsis of some of the more important natural polymers. It will close with a summary of some of the very significant environmental problems created by the wide use of plastics.