BBMB - Chapter 28 (Fatty Acid Synthesis) Flashcards | …


Fatty synthesis and fatty acid elongation are two parts of a critically important in plants. The endproducts are essential components of cell membranes, waxes, and . Two chemical families of (groups that share similar chemical structures) inhibit fatty acid synthesis, while fatty acid elongation is inhibited by two other families. This lesson will provide an overview of fatty acid synthesis and elongation, and explain where herbicides inhibit the pathway. Mechanisms of to these herbicides will be described.


At the completion of the lesson, students will be able to:

Fatty acid synthesis - Wikipedia

: The first of fatty acid synthesis is acetyl CoA-carboxylase (ACCase; EC, which the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA . ACCase carries out the first committed step and is thus the regulatory site for the whole . The enzyme is composed of two monomers with different functions: a biotin carboxylase complex and a carboxyltransferase complex. Higher plants have two forms of ACCase: a eukaryotic, cytosolic form that is mostly to herbicides and a prokaryotic, plastidic form that is to herbicides. The plastidic enzyme is further subdivided into two isoforms: a dimeric form found in most monocots and all , and an unusual multidomain form found only in graminaceous monocots. Biochemical investigations on the for ACCase-inhibiting herbicides show that they interact with a 400-amino acid region of the carboxyltransferase of the enzyme.

Inhibitors of Fatty Acid Synthesis and ..

acid biosynthetic pathway and its cellular location in ..

Thus, peroxidation of (n-6) fatty acids (linoleic andarachidonic acids) produces well defined compounds, 2,4-decadienal and 3-nonenal from9-hydroperoxy linoleate, hexanal and pentanal from 13-hydroperoxy linoleate, and2-heptenal from 10-hydroperoxy linoleate.
Other volatile decomposition compounds are frequently found: 2-hexenal, 2-octenal, 2,4-nonadienal,4,5-dihydroxydecenal and especially 4-hydroxy-2,3-trans-nonenal (4HNE).