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Felix Konotey-Ahulu, an authority on sickle-cell anemia:
Cabeen MT and Jacobs‐Wagner C (2007) Skin and bones: the bacterial cytoskeleton, cell wall, and cell morphogenesis. Journal of Cell Biology 179: 381–387.
Tertiary Structure of Staphylococcus aureus Cell Wall Murein
Colicin M inhibited the incorporation of DL + meso-2,6-diamino[3,4,5-3H]pimelic acid into the murein (peptidoglycan) of growing cells of Escherichia coli W7 dap lys. The inhibition of the UDP-N-acetylmuramyl pentapeptide-dependent incorporation of UDP-N-acetyl-D-[U-14C]glucosamine into isolated cell envelopes indicated interference with a late step of murein biosynthesis. After the inhibition of murein biosynthesis, cells lysed, and they released lysis products of murein. In vitro, the murein biosynthesis of colicin M-tolerant mutants (tolM) was inhibited by colicin M. Therefore, tolerance is probably conferred by an impaired uptake of an altered fixation close to the target site and not by a mutation of the target itself. Preliminary studies with beta-lactam antibiotics and with mutants in penicillin-binding proteins did not reveal a specific enzymatic step inhibited by colicin M. The unique action among the colicins renders colicin M a potentially useful tool for studying murein biosynthesis.
Murein biosynthesis in ether ..
A group of temperature-sensitive lysis mutants of Escherichia coli K-12 was studied. Mutants impaired in the synthesis of uridine diphosphate-N-acetylmuramyl (UDP-MurNAc)-pentapeptide or in the synthesis of murein amino acids were found. Their rate of murein synthesis at the restrictive temperature was decreased. A large number of mutants did not differ from the parent strain with respect to the rate of murein synthesis and the precursor pattern. The behavior of these mutants is discussed. It was impossible to accumulate UDP-MurNAc-pentapeptide in E. coli by the antibiotics penicillin and vancomycin. The hypothesis is put forward that the amount of this murein precursor is regulated by feedback inhibition.
Peptidoglycan structure and biosynthesis - VidInfo
Most of these microorganisms form some type of asporeor other dormant cell, and there is thought to be some relationship(besidestemporal) between antibiotic production and the processes ofsporulation.
Peptidoglycan structure and biosynthesis ..
A more broadened definition of anantibioticincludes any chemical of natural origin (from any type of cell) whichhasthe effect to kill or inhibit the growth of other types cells.