Synthesis and evaluations of bisphosphonate …

The presence of zoledronate or vanadium correlated with the most potent activity (IC50-1-5 μM) against three human tumor cell lines.AB - Figure Persented: We report the synthesis and characterization of eight new Mo, W, or V-containing polyoxometalate (POM) bisphosphonate complexes with metal nuclearities ranging from 1 to 6.

Synthesis and evaluation of a novel 68Ga-chelate-conjugated bisphosphonate as a bone-seeking ..

MarlenyAU - Mialane,PierreAU - Marrot,JérômeAU - Vila,NeusAU - Mbomekallé,Israel MartyrAU - Rivière,EricAU - Duboc,CaroleAU - Dolbecq,AnnePY - 2012/7/16Y1 - 2012/7/16N2 - Figure Persented: We report the synthesis and characterization of eight new Mo, W, or V-containing polyoxometalate (POM) bisphosphonate complexes with metal nuclearities ranging from 1 to 6.


Bisphosphonate sequestering agents

Read "Bisphosphonate prodrugs: Synthesis and biological evaluation in HuH7 hepatocarcinoma cells, European Journal of Medicinal Chemistry" on …

Abstract: In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems.