Biosynthesis of Conjugated Linoleic Acid ..

These figures showed three peaks at 215 nm, 232 and 270 nm representing respectively linoleic acid, rumenic acid and α-ESA. There were no conjugated s in rat tissues immediately before administration of the oil, but only the peak of linoleic acid appeared.

Occurrence of conjugated linoleic acid in ruminant products and its physiological functions

reported that alkali-isomerization of linoleic acid gave amixture of cis-9,trans-11- and trans-10,cis-12-octadecadienoic acid, now knownas conjugated linoleic acids (CLA) ().

Folch J et al.


biology of conjugated linoleic acid in ruminants.

89, 2556–2570.
| | |

Chin SF, Liu W, Storkson JM, Pariza MW (1992) Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens.


Conjugated Linoleic Acid (CLA) is supporting ..

All these species have in common 4 conjugated all-cis double bonds as in 18:4 with their position in 6,8,10, and 12, the novel conjugated docosaheptadecanoic acid having its double bonds in 4, 7, 9, 11, 13, 16, and 19, it was named stellaheptaenoic acid.

The expression of cDNAs for variant forms of the delta12-oleic acid desaturase in transgenic soybean embryos resulted in the production of conjugated polyenes ().

A review has summarized and updated the evidence regarding the metabolism and bioactivities of conjugated linolenic acid, and discussed the recent studies on the effects of anti-carcinogenic, lipid metabolism regulation, anti-inflammatory, anti-obese and
antioxidant activities of the variousisomers (., Food Funct 2014, 5, 1360).

Biosynthesis of conjugated linoleic acid in ruminants and ..

bignonoides where it accounts for 50% of all the conjugated linolenic acid content (27.5% of the oil) (). Catalpa () seed oil suppresses chemically-induced cell proliferation in rat colon (, Oncol Rep 2006, 16, 989).

Effect of conjugated linoleic acid supplementation on body ..

demonstrated for the first time the presence of conjugated linoleic acids (CLA)in animal products which were shown to inhibit mutagenesis in bacteria and theinitiation of epidermal carcinogenesis in mice ().

Discovery of a hormone-like compound, a sesquiterpenoid (methyl farnesoate) incrustaceans, now considered as the crustacean juvenile hormone (Borst DW et al.,Insect Biochem 1987, 17, 1123).

Demonstration of ceramide generation from sphingomyelin after activation of anacid sphingomyelinase by diacylglycerols ().

Conjugated Linoleic Acid Review and Dosage - …

Furthermore, CLA, as other conjugated fatty acids, has antioxidative activity which could be related to their anticarcinogenic and anti-atherosclerotic effects ().

For a review on the occurrence and physiological properties of trans fatty acids and on CLA, see: Fritsche J et al.