Organolithium can spontaneously catch fire in air and it can react with water, which makes unwanted reactions appear where water exists. The method the chemist team developed to overcome such issues is cheap and green. It’s said the main material needed for the preparation of the replacement is used as chicken feed, from which it can be judged that the cost should be much lower than the conventional version.
Organofluorine compounds are the chemicals that include difluoromethyl group (CF2H), which plays an important role in pharmaceutical, agrochemical activities as fluorine atoms were introduced during the process. The adding of fluorine atoms to a chemical would change the chemical properties and then the medical performance. Thus it’s a quite effective way to expand compounds’ pharmaceutical characters.
Bio-organic Synthesis - Leiden University
The use of such enolate anions from carbonyl compounds is fundamental to organic synthesis and you will already have met them as intermediates in the Aldol reaction and Claisen condensation.
Organic Synthesis | Organic Synthesis Information Blog
Organolithium is an essential part for organic chemistry like chemistry synthesis, but with great danger to apply them in practice. A lot of accidents caused by the applications in researches, then developing an alternative to replace it while improve efficiency and save budget was conceived. Finally, an ideal replacement was found by a research team led by Eva Hevia and composed of chemists from UK and Spain.
Organic Chemistry - American Chemical Society
The research article is published on Wiley Online Library and titled in Exploiting Deep Eutectic Solvents and Organolithium Reagent Partnerships: Chemoselective Ultrafast Addition to Imines and Quinolines Under Aerobic Ambient Temperature Conditions.
Biomimetic Organic Synthesis - Wiley Online Library
– a paper operation involving an imagined cleavage of a bond (yielding ‘synthons’) to suggest a method and possible SM’s for making the bond, ultimately leading to possible SM’s for the overall synthesis.
Chemical Biology and Bio-organic Group Forum
We will illustrate this approach with examples, starting with synthesis of benzene derivatives. Starting point is usually fairly obvious – simple benzene derivatives or perhaps benzene itself.
Chemical Biology and Bio-organic Group ..
Our research lies at the interface of organic chemistry and chemical biology. We aim to develop versatile new synthetic tools for small molecule synthesis, protein bioconjugation, and the design of peptide-based therapeutics. By expanding the toolbox of practical methods and reagents for the direct modification of complex biomolecules, we seek to understand their role in mediating biological processes as well as enhance their therapeutic potential.