(1989) Naphthalene 1.3 1987 Slooff et al.

Korn S, Moles D, & Rice SD (1979) Effects of temperature on the median tolerance limit of pink salmon and shrimp exposed to toluene, naphthalene, and Cook Inlet crude oil.

Naphthalene Embryotoxicity Toxicity in cultured embryos

Doses of 51.4 mg/kg bw per day acenaphthene or 180 mg/kg bw per day fluorene induced a significant increase in the rate of liver regeneration, but 15.4 mg/kg bw per day acenaphthene, 51.4 mg/kg bw per day benzo [a]pyrene, or 514 mg/kg bw per day pyrene, anthracene, or phenanthracene had no effect (Gershbein, 1975).

(1990) Acenaphthylene 3.83 RP-HPLC on CIHAC Szabo et al.

The oxidation products of naphthalene may reach the eye via the bloodstream, where 1,2-naphthoquinone is formed which can react with proteins and other cell components to form insoluble precipitates with a characteristic brown colour (Van Heyningen & Pirie, 1967).

There were problems with the solubility of indeno[1,2,3- cd]pyrene.

ICR/Ha benzo[a]pyrene, 3x/wk, effect on skin tumours; no/val (1978) 78 weeks; co-carcinogenicity naphthalene only: no skin test tumours 98-99% Mouse, f 30 Inha- 0.05 and 0.15 mg/l, 6 months 29 and 30% with pulmonary q Adkins et al.

Feeding of 1-naphthol did not induce opacification (Xu et al., 1992).

Swiss initiaton experiment no tumours no/val (1981b) Ha/ICR Naphthalene Mouse Dermal Several times/wk, < 11 No skin tumours n Kennaway < 11 months months no/lc (1930) Highly Mouse, 25; Dermal 0.5% in benzene, 6x/week Life 4/25 with lymphatic q Knake (1956) purified SW inbred con- for 3 weeks, then 2x/wk for leukaemia; 1/25 lymphosarcoma no/lc, trol: life of thymus; 4/25 with benign ln 21 tumours; benzene only: 2/21 with sarcomas; 1/21 with lung adenoma Table 90.

Bourne MC & Young L (1934) The metabolism of naphthalene in rabbits.

The authors concluded that P450-dependent bioactivation was necessary to form reactive intermediates, which are assumed to be naphthoqninone or a free-radical derivative (Wells et al., 1989).

Environ Health Perspectives, 102: 61-66.

Syrian 157 (average no/val (1964) latency) Hamster, m 4/34 Intra- 0.5 and 2 mg/animal, < 110 Tumours (i) 6/44 (trachea), p Sellakumar & Syrian tracheal weekly, 24 and 4 weeks, weeks 37/44 (bronchi), 2/34 yes/val Shubik (1974) golden respectively (trachea); (ii) 1/34 (larynx), 13/34 (bronchi); control: no tumours Hamster, m/f 24/24 Intra- 0.5 and 1 mg/animal, 65 and 75% respiratory p Stenback & Syrian tracheal 1 x/week, 17 and 12 weeks, tumours (bronchi, trachea); no/ld Sellakumar golden respectively shortest latency: 8 weeks (1974) Table 90.

Collin G & Höke H (1991) Naphthalene and hydronaphthalene.

sacrifice Acenaphthene Mouse 100 Dermal Dissolved in 90% benzene 9 months No tumours observed n Kennaway no/lc (1924) 'Pure' Mouse, m 85 Dermal 3 drops, 1x/week of <1 year After 12 months 5/85 survived q Graffi et al.