Korn S, Moles D, & Rice SD (1979) Effects of temperature on the median tolerance limit of pink salmon and shrimp exposed to toluene, naphthalene, and Cook Inlet crude oil.
Doses of 51.4 mg/kg bw per day acenaphthene or 180 mg/kg bw per day fluorene induced a significant increase in the rate of liver regeneration, but 15.4 mg/kg bw per day acenaphthene, 51.4 mg/kg bw per day benzo [a]pyrene, or 514 mg/kg bw per day pyrene, anthracene, or phenanthracene had no effect (Gershbein, 1975).
(1990) Acenaphthylene 3.83 RP-HPLC on CIHAC Szabo et al.
The oxidation products of naphthalene may reach the eye via the bloodstream, where 1,2-naphthoquinone is formed which can react with proteins and other cell components to form insoluble precipitates with a characteristic brown colour (Van Heyningen & Pirie, 1967).
There were problems with the solubility of indeno[1,2,3- cd]pyrene.
ICR/Ha benzo[a]pyrene, 3x/wk, effect on skin tumours; no/val (1978) 78 weeks; co-carcinogenicity naphthalene only: no skin test tumours 98-99% Mouse, f 30 Inha- 0.05 and 0.15 mg/l, 6 months 29 and 30% with pulmonary q Adkins et al.
Feeding of 1-naphthol did not induce opacification (Xu et al., 1992).
Swiss initiaton experiment no tumours no/val (1981b) Ha/ICR Naphthalene Mouse Dermal Several times/wk, < 11 No skin tumours n Kennaway < 11 months months no/lc (1930) Highly Mouse, 25; Dermal 0.5% in benzene, 6x/week Life 4/25 with lymphatic q Knake (1956) purified SW inbred con- for 3 weeks, then 2x/wk for leukaemia; 1/25 lymphosarcoma no/lc, trol: life of thymus; 4/25 with benign ln 21 tumours; benzene only: 2/21 with sarcomas; 1/21 with lung adenoma Table 90.
Bourne MC & Young L (1934) The metabolism of naphthalene in rabbits.
The authors concluded that P450-dependent bioactivation was necessary to form reactive intermediates, which are assumed to be naphthoqninone or a free-radical derivative (Wells et al., 1989).
Environ Health Perspectives, 102: 61-66.
Syrian 157 (average no/val (1964) latency) Hamster, m 4/34 Intra- 0.5 and 2 mg/animal, < 110 Tumours (i) 6/44 (trachea), p Sellakumar & Syrian tracheal weekly, 24 and 4 weeks, weeks 37/44 (bronchi), 2/34 yes/val Shubik (1974) golden respectively (trachea); (ii) 1/34 (larynx), 13/34 (bronchi); control: no tumours Hamster, m/f 24/24 Intra- 0.5 and 1 mg/animal, 65 and 75% respiratory p Stenback & Syrian tracheal 1 x/week, 17 and 12 weeks, tumours (bronchi, trachea); no/ld Sellakumar golden respectively shortest latency: 8 weeks (1974) Table 90.
Collin G & Höke H (1991) Naphthalene and hydronaphthalene.
sacrifice Acenaphthene Mouse 100 Dermal Dissolved in 90% benzene 9 months No tumours observed n Kennaway no/lc (1924) 'Pure' Mouse, m 85 Dermal 3 drops, 1x/week of <1 year After 12 months 5/85 survived q Graffi et al.