Julien delivered an invited lecture titled "Innovative Polymers for Drug Delivery Applications" at the Chemistry division of the French Academy of Sciences, Paris, France.
The synthesis of polymers with latent reactivity suitable for ‘click’ type modifications in a tandem post-polymerisation modification process starting with poly(azlactone) precursors is investigated. Poly(azlactones), obtained by copper(I) mediated radical polymerisation, were functionalised in a one-pot process with amines bearing functional groups which are incompatible with controlled radical polymerisation: alkynes, alkenes, furfuryl and phenol. The reaction is quantitative and 100% atom efficient presenting an efficient route to clickable scaffolds without the need for protecting group chemistry. Additionally, the poly(azlactones) were exploited to obtain synthetic glycopolymers. The ring opening procedure introduces a 5-atom spacer between glycan and backbone, which provides improved access to carbohydrate-binding proteins with deep binding pockets, such as the cholera toxin, for anti-adhesion applications.
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Yinyin's article titled "Hydrophobic or PEGylated, Self-Stabilized Paclitaxel Polymer Prodrug Nanoparticles for Cancer Therapy" is accepted in Polym. Chem. Congrats!
Azlactone synthesis | Article about Azlactone synthesis …
Press release by the CNRS concerning our collaborative article in Angewandte Chemie, International Edition, titled: "Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters"
04/12/2017 · Looking for Azlactone synthesis
Our collaborative paper (with Didier Gigmes and Didier Letourneur's groups) titled "Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters" is accepted in Angew. Chem., Int. Ed. Congrats to all!
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Elise delivered a lecture titled "Development of Degradable Polymer Prodrug Nanoparticles for Cancer Therapy" at the 34ème Club Emulsion, Lyon, France. Congrats!
Erlenmeyer–Plöchl azlactone synthesis | SpringerLink
Congratulations to Elise who successfully defended her PhD, titled "Degradable Polymer Prodrugs Synthesized by Nitroxide-Mediated Radical Ring-Opening Polymerization" in front of the following committee: Sophie Guillaume, Sagrario Pascual, Sébastien Lecommandoux, Philippe Guégan, Yohann Guillaneuf, Elias Fattal, Patrick Couvreur and Julien Nicolas.
One-Step Synthesis of Azlactone-Functionalized SG1 …
Megan's paper (collaboration with Brent Sumerlin's group) titled "Radical Ring-Opening Copolymerization of Cyclic Ketene Acetals and Maleimides Affords Homogeneous Incorporation of Degradable Units" is accepted in ACS Macro Letters. Congrats!