The development of new methods for the efficient synthesis of aziridines has been of considerable interest to researchers for more than 60 years, but no single method has yet emerged as uniformly applicable, especially for asymmetric synthesis of chiral aziridines. One method which has been intensely examined and expanded of late involves the nucleophilic addition to imines by anions bearing a-leaving groups; by analogy with the glycidate epoxide synthesis, these processes are often described as "aza-Darzens reactions". This Microreview gives a summary of the area, with a focus on contemporary developments. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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J.; Buerkstuemmer, E.; Linclau, B., Short Synthesis of Enantiopure 2-Symmetric 1,2:4,5-Diepoxypentane and "Pseudo"-2-Symmetric 3-Azido-1,2:4,5-diepoxypentane from Arabitol.
Aziridines and Epoxides in Organic Synthesis | Request …
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crookwellense (1993) Toxins derived from Fusarium sporotrichioides (1993) Trichlorfon () Trichloroacetic acid () (1995) Trichloroacetonitrile () (1991) 1,1,1-Trichloroethane () 1,1,2-Trichloroethane () (1991) Triethylene glycol diglydicyl ether () Trifluralin () (1991) 4,4´,6-Trimethylangelicin () plus ultraviolet radiation 2,4,5-Trimethylaniline () 2,4,6-Trimethylaniline () 4,5´,8-Trimethylpsoralen () 2,4,6-Trinitrotoluene () (1996) Triphenylene () Tris(aziridinyl)-p-benzoquinone (Triaziquone) () Tris(1-aziridinyl)phosphine oxide () 2,4,6-Tris(1-aziridinyl)-s-triazine () Tris(2-chloroethyl)phosphate () (1990) 1,2,3-Tris(chloromethoxy)propane () Tris(2-methyl-1-aziridinyl)phosphine oxide () Vat Yellow 4 () (1990) Vinblastine sulphate () Vincristine sulphate () Vinyl acetate () Vinyl chloride-vinyl acetate copolymers () Vinylidene chloride () Vinylidene chloride-vinyl chloride copolymers () Vinylidene fluoride () N-Vinyl-2-pyrrolidone () Vinyl toluene () (1994) Wollastonite () Xylene () (1989) 2,4-Xylidine () 2,5-Xylidine () Yellow AB () Yellow OB () Zectran () Zeolites () other than erionite (clinoptilolite, phillipsite, mordenite, non-fibrous Japanese zeolite, synthetic zeolites) (1997) Zineb () Ziram () (1991)Betel quid, without tobacco Bitumens (), steam-refined, cracking-residue and air-refined Crude oil () (1989) Diesel fuels, distillate (light) (1989) Fuel oils, distillate (light) (1989) Jet fuel (1989) Mate (1990) Mineral oils, highly refined Petroleum solvents (1989) Printing inks (1996) Tea (1991) Terpene polychlorinates (StrobaneR) ()Flat-glass and specialty glass (manufacture of) (1993) Hair colouring products (personal use of) (1993) Leather goods manufacture Leather tanning and processing Lumber and sawmill industries (including logging) Paint manufacture (occupational exposure in) (1989) Pulp and paper manufactureCaprolactam ()1 Chemical Abstract Number and year are given in parentheses: year in which the evaluation was published subsequent to the Supplement 7 Working Group for agents, mixtures or exposure circumstances considered in Volumes 43 to 61 of the Monographs.