Symmetrical 1,3,5-triazine is the common.

N2 - A new synthesis of N1-(substituted)-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones, which are analogues of the natural product toxoflavin, is reported. Condensation of preformed alkyl or aryl hydrazones with 6-chloro-3-methyl-5-nitrouracil efficiently provides pyrimidotriazinediones in a three-step process that broadens the scope of R1 substituents.

T1 - A novel synthesis of N1-(substituted)-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones

The structural variation of imidazo[1,2,4]triazine derivatives poses a significant challenge, particularly if a broad variety of substituents is to be introduced. Several synthetic strategies involving combinatorial and sequential approaches, in particular intramolecular cyclocondensation reactions of functionalized 1,2,4-triazole and imidazole precursors, have been developed [–].

KW - Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones

1155 Sixteenth Street N.W.Washington, DC 20036

Dihydroimidazo[5,1-c][1,2,4]triazine-3,6(2H,4H)-dione derivatives were prepared by successive N3- and N1-alkylation of hydantoins, followed by regioselective thionation and subsequent cyclization under mild conditions. In a final alkylation step a further substituent may be introduced. The synthetic strategy allows broad structural variation of this new drug-like heterobicyclic scaffold. In addition to extensive NMR and MS analyses, the structure of one derivative was confirmed by X-ray crystallography.

Synthesis of 1,2,3-triazine N-oxides - ResearchGate

Triazines are basic structure of herbicides, examples are amitole (CAS #: 61-82-5), atrazine (CAS #: 1912-24-9), cyanazine (CAS #: 21725-46-2), simazine (CAS #: 122-34-9), trietazine (CAS #: 1912-26-1).


Large volume of triazines are used in the manufacture of resin modifiers such as melamine and benzoguanamine. Melamine (1,3,5-Triazine-2,4,6-triamine) is reacted with formaldehyde to from a very durable thermoset resin.

Preparation of 2,4,6-tris(trifluoromethyl)-1,3,5-triazine

Triazines are six-membered heterocyclic aromatic compounds containing three nitrogen atoms in the ring. Triazines exist in three isomeric forms viz., 1,2,3-triazine, 1,2,4-triazine, and 1,3,5-triazine (s-triazine). Compared to benzene, the resonance energy of triazines is very less, and hence less aromatic than benzene.

The 1,3,5-triazine unit has been used as a key functional group in host-guest chemistry owing the formation of three strong hydrogen bonds with the host molecule. The less expensive triazine based reagent cyanuric chloride has been successfully used in the synthesis of substituted 1,3,5-triazines by controlled nucleophilic substitutions. As an alternative to Swern oxidation, cyanuric acid has been used for the conversion of alcohols to formates and alkyl chlorides, and the carboxylic acids into hydroxamic acids, acid chlorides, 2-oxazolines, esters, alcohols and amides (for a review: Use of the ring opening reactions of 1,3,5-triazines in Organic Synthesis. Aksenov, A.V. et al. Chemistry of Heterocyclic Compounds, 2009, 45(2), 130-150).

Generally, triazines play a vital role in many biological processes and synthetic drug chemistry. They constitute core structure in many chemotherapeutic agents, which includes anti-HIV, antibacterial, anti-angiogenesis, and antimalarial activities. In addition, the s-triazine ring containing compounds have also found application in pesticides, resin intermediates, dyes and explosives


A triazine is class of nitrogen-containing . The parent molecules' is 333. They exist in three isomeric forms, 1,3,5-triazines being common.